By Christopher J. Gordon

Thermoregulation is essential for survival however the interaction among poisonous insults and thermoregulatory mechanisms is frequently poorly understood. Temperature and Toxicology: An Integrative, Comparative, and Environmental strategy is the 1st significant textual content to review the integrative thermoregulatory responses of mammals which are uncovered to toxicants. simply because environmental body structure is usually the most important in toxicological responses, this quantity additionally examines the position of environmental temperature within the modulation of mobile mechanisms of toxicity.

The e-book starts off via explaining the significance of temperature in toxicological reviews, and the way all organic strategies are depending on temperature. It then reports the fundamentals of temperature rules in homeotherms and poikilotherms, and addresses whole-animal and in vitro stories concerning the consequences of temperature on toxicity. The textual content examines thermoregulatory reaction to poisonous insult, and the way responses impact restoration and strength survival. It describes hypothermic reaction in rodents to febrile and hyperthermic reactions in people, and discusses the relevance of warmth and chilly tension on human exposures to airborne toxins and different toxicants.

This quantity presents an in depth comparability of physiological responses of invertebrates, fish, amphibians, and mammals, and specializes in the impression of endocrine disruption. It then considers how toxicants and thermal pressure reason the expression of rigidity proteins, through a research of the effect of genetic variability. The ebook concludes with an exam of thermoregulatory reaction to normal pollutants and venoms.

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Temperature and Toxicology: An Integrative, Comparative, and Environmental Approach by Christopher J. Gordon


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