By Alexander Dömling

Treating protein-protein interactions as a singular and hugely promising category of drug pursuits, this quantity introduces the underlying options step-by-step, from the biology of PPIs to biophysical and computational tools for his or her research.
the most a part of the publication describes examples of protein pursuits for which small molecule modulators were constructed, protecting such diversified fields as melanoma, autoimmune issues and infectious ailments. tailored for the working towards medicinal chemist, this prepared reference incorporates a big choice of case experiences taken instantly from the improvement pipeline of significant pharmaceutical businesses to demonstrate the facility and capability of this approach.

From the contents:

* Prediction of intra- and inter-species protein-protein interactions facilitating platforms biology studies
* Modulators of protein-protein interactions: the significance of Three-Dimensionality
* Interactive applied sciences for leveraging the recognized chemistry of anchor residues
* SH3 domain names as Drug Targets
* P53 MDM2 Antagonists: in the direction of Non Genotoxic Anticancer Treatments
* Inhibition of LFA-1/ICAM interplay for therapy of autoimmune diseases
* The PIF-binding pocket of AGC kinases
* Peptidic inhibitors of protein-protein interactions for mobile adhesion receptors
* The change technique for producing Non-ATP aggressive Inhibitors of Cell-Cycle Protein Kinases

and more

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Protein-Protein Interactions in Drug Discovery, Volume 56 (Methods and Principles in Medicinal Chemistry) by Alexander Dömling


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