By Amy M. Fulton

Chemokines are a superfamily of low molecular weight cytokines that have been firstly defined in response to their skill to urge the directed migration of leukocytes to websites of irritation or harm. In people, there are nearly forty five chemokines that bind to 19 G-protein-coupled receptors. as well as mediating mobile migration, chemokines have now been proven to impact many mobile services together with survival, adhesion, invasion, proliferation, and to manage circulating chemokine degrees. even supposing chemokine receptors have been first defined on leukocytes, it's now favored that chemokine receptors also are expressed through many different cells together with endothelial and epithelial cells.


Since the 1st description of chemokine receptors on malignant cells in 2001, an intensive literature has built describing the expression and serve as of chemokine receptors in lots of malignancies. those stories help the preliminary speculation that malignant cells use chemokine receptors emigrate to far-off websites of ligand expression and that expression of convinced receptors is linked to a negative diagnosis. It has additionally turn into obvious that malignancies of other tissues may possibly use a various profile of chemokine receptors and that an analogous receptor may possibly mediate metastasis to varied websites in tumors of alternative histological origins. Receptor functionality can also keep survival and growth of the first tumor.

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Chemokine Receptors in Cancer (Cancer Drug Discovery and Development) by Amy M. Fulton


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